Nogalamycin

Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2].

Product Specifications

CAS Number

[1404-15-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332, H350, H360

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nogalamycin.html

Purity

97.2

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=C(C(C3=C1C=C4C([C@H](C[C@](C)(O)[C@@H]4C(OC)=O)O[C@@]5([H])[C@@H]([C@@](C)([C@@H](OC)[C@H](C)O5)OC)OC)=C3O)=O)C(O)=CC6=C2O[C@]([C@@H](O)[C@H](N(C)C)[C@H]7O)([H])O[C@]67C

Molecular Formula

C39H49NO16

Molecular Weight

787.80

Precautions

H302, H312, H332, H350, H360

References & Citations

[1]Bhuyan BK, et al. Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture. Cancer Res. 1981;41 (1) :18-24.|[2]Bhuyan BK, et al. Differential interaction of nogalamycin with DNA of varying base composition. Proc Natl Acad Sci U S A. 1965;54 (2) :566-572.|[3]Bempong MA. Cytological effect of nogalamycin in mammals and regression of methylcholanthrene-induced and spontaneous tumors in rats. Int J Clin Pharmacol Biopharm. 1976;14 (1) :6-14.