Mazaticol

Mazaticol is an anticholinergic agent. Mazaticol blocks the muscarinic acetylcholine receptors and cholinergic nerve activity. Mazaticol is a potent 3H-QNB and 3H-PZ binding inhibitor, can bind to the M2 receptors with high affinity. Mazaticol exhibits inhibitory effects on dopamine uptake in the striatal nerve terminal. Mazaticol can be used for parkinsonian syndrome research[1][2].

Product Specifications

CAS Number

[42024-98-6]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mazaticol.html

Solubility

10 mM in DMSO

Smiles

CC1(C)[C@H](N(C)[C@H](CC1)C2)C[C@@H]2OC(C(C3=CC=CS3)(C4=CC=CS4)O)=O

Molecular Formula

C21H27NO3S2

Molecular Weight

405.57

References & Citations

[1]Niimi Y, et al. Mazaticol for Treating Parkinson. 2020.|[2]Katayama S, et al. Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain. Res Commun Chem Pathol Pharmacol. 1990;69 (3) :261-270.