Ponesimod-d4
Ponesimod-d4 (ACT-128800-d4) is the deuterium labeled Ponesimod. Ponesimod (ACT-128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod activates S1P1-mediated signal transduction with high potency (EC50=5.7 nM). Ponesimod can protect against lymphocyte-mediated tissue inflammation[2][3][4].
Product Specifications
Product Name Alternative
ACT-128800-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; LPL Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC
Molecular Formula
C23H21D4ClN2O4S
Molecular Weight
465.00
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Peripheral Benzodiazepine Receptor (PBR, Peripheral Type Benzodiazepine Receptor, PTBR, Benzodiazapine Receptor (Peripheral), BZRP, Benzodiazepine Peripheral Binding Site, DBI, IBP, mDRC, Mitochondrial Benzodiazepine Receptor, MBR, pk18, PKBS, Translocator Protein (18kD), TSPO) (Control Peptide) discontinued
ALG1L6P (Asparagine-Linked Glycosylation 1 Homolog Pseudogene)
Anti-Caspase-3 (P17) /CASP3 Antibody Picoband® Fluoro594 Conjugated
