TC-E 5005

TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1].

Product Specifications

CAS Number

[959705-64-7]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tc-e-5005.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C2C(N3C(C(C)=N2)=C(C)N=C3CCC)=N1

Molecular Formula

C15H18N4O

Molecular Weight

270.33

References & Citations

[1]Hennenberg M, et al. Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005. Prostate. 2016 Nov;76 (15) :1364-74.