TC-E 5005
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1].
Product Specifications
CAS Number
959705-64-7
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tc-e-5005.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2C(N3C(C(C)=N2)=C(C)N=C3CCC)=N1
Molecular Formula
C15H18N4O
Molecular Weight
270.33
References & Citations
[1]Hennenberg M, et al. Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005. Prostate. 2016 Nov;76 (15) :1364-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10; PDE11; PDE2; PDE3; PDE5; PDE7
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