Nomegestrol

Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

Product Specifications

CAS Number

[58691-88-6]

UNSPSC

12352211

Hazard Statement

H315-H319-H320

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Nomegestrol.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@]([C@]4([H])C(C(C)=C3)=CC(CC4)=O)([H])CC1

Molecular Formula

C21H28O3

Molecular Weight

328.45

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56 (6) :325-8.|[2]Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76 (6) :531-9.