PF-10040
PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis[1][2].
Product Specifications
CAS Number
132928-46-2
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-10040.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=CC(CCC2=NCCC3=CC(C)=CC=C23)=C1.Cl
Molecular Formula
C20H24ClNO2
Molecular Weight
345.86
References & Citations
[1]Herd CM, et, al. Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 1994 Jan;111 (1) :7-12. |[2]Wallace JL, et, al. Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF. J Lipid Mediat. 1993 Jun;7 (2) :183-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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