FR 113680

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1].

Product Specifications

CAS Number

[126088-92-4]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fr-113680.html

Solubility

10 mM in DMSO

Smiles

CN(CC1=CC=CC=C1)C([C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H]([C@H](O)C)NC(C)=O)=O)CC3=CN(C=O)C4=C3C=CC=C4)=O)=O

Molecular Formula

C35H39N5O6

Molecular Weight

625.71

References & Citations

[1]Morimoto H, et al. FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106 (1) :123-6.|[2]Morimoto H, et al. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224 (1) :1-5.