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(Z) -GW 5074

(Z) -GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z) -GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].

Product Specifications

CAS Number

1233748-60-1

UNSPSC

12352005

Target

Atg8/LC3; Raf

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z-gw-5074.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3.[Z]

Molecular Formula

C15H8Br2INO2

Molecular Weight

520.94

References & Citations

[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

C-Raf

Frequently Asked Questions

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