(Z) -GW 5074
(Z) -GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z) -GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].
Product Specifications
CAS Number
1233748-60-1
UNSPSC
12352005
Target
Atg8/LC3; Raf
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z-gw-5074.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3.[Z]
Molecular Formula
C15H8Br2INO2
Molecular Weight
520.94
References & Citations
[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
C-Raf
Frequently Asked Questions
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