Calphostin C

Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications[1][2][3].

Product Specifications

CAS Number

[121263-19-2]

Product Name Alternative

UCN-1028C

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Antibiotic; Apoptosis; PKC

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/calphostin-c.html

Purity

99.9

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

O=C(O[C@@H](CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(C[C@@H](C)OC(C6=CC=CC=C6)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O

Molecular Formula

C44H38O14

Molecular Weight

790.76

Precautions

H302, H315, H319

References & Citations

[1]Kobayashi E, et al. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1989;159 (2) :548-553.|[2]Chen CL, et al. Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity. Pharm Res. 1999 Jul;16 (7) :1003-9.|[3]Hermenegildo C, et al. Sustained recovery of Na (+) -K (+) -ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC. Diabetes. 1993 Feb;42 (2) :257-62.