Heliquinomycin

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].

Product Specifications

CAS Number

[178182-49-5]

UNSPSC

12352005

Hazard Statement

H302+H312, H319

Target

Bacterial; DNA/RNA Synthesis; Topoisomerase

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/heliquinomycin.html

Solubility

10 mM in DMSO

Smiles

OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O

Molecular Formula

C33H30O17

Molecular Weight

698.58

Precautions

H302+H312, H319

References & Citations

[1]Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) . 1996 Aug;49 (8) :752-7. |[2]Chino M, et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo) . 1998 May;51 (5) :480-6.