CEP-9722
CEP-9722, the proagent of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].
Product Specifications
CAS Number
[916574-83-9]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cep-9722.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CN2CCN(C)CC2)C3=C4C5=C(OC)C=CC=C5NC4=C6C(CCC6)=C3C1=O
Molecular Formula
C24H26N4O3
Molecular Weight
418.49
References & Citations
[1]Weiguo Jian, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014 Sep;25 (8) :878-86.|[2]Ruth Plummer, et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Aug;74 (2) :257-65.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105303/CEP-9722-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105303/
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PARP1; PARP2
Available Sizes
Curated Selection
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