Loreclezole (hydrochloride)

Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

Product Specifications

CAS Number

[2227372-56-5]

Product Name Alternative

R 72063 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/loreclezole-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(/C(Cl)=C/N2N=CN=C2)C(Cl)=C1.[H]Cl

Molecular Formula

C10H7Cl4N3

Molecular Weight

310.99

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91 (10) :4569-73.|[2]Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35 (12) :1753-60.|[3]Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35 (9-10) :1243-50.