PARP-2/1-IN-2

PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].

Product Specifications

CAS Number

[912444-01-0]

UNSPSC

12352005

Hazard Statement

H302-H317

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/parp-2-1-in-2.html

Solubility

10 mM in DMSO

Smiles

NC(C1=C2C(N=C([C@]3(C)CCCN3)N2)=CC=C1)=O

Molecular Formula

C13H16N4O

Molecular Weight

244.29

Precautions

P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Ta LE, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8 (1) :e54161.