PARP-2/1-IN-2
PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib , is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].
Product Specifications
CAS Number
912444-01-0
UNSPSC
12352005
Hazard Statement
H302-H317
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/parp-2-1-in-2.html
Solubility
10 mM in DMSO
Smiles
NC(C1=C2C(N=C([C@]3(C)CCCN3)N2)=CC=C1)=O
Molecular Formula
C13H16N4O
Molecular Weight
244.29
Precautions
P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Ta LE, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8 (1) :e54161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Frequently Asked Questions
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