Eesperamicin A1

Esperamicin A1, as an extremely potent antitumor antibiotic, is isolated from cultures of Actinomadura verrucosospora. Esperamicin A1 can be used for the research of antitumor[1]. Eesperamicin A1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[99674-26-7]

UNSPSC

12352005

Target

Antibiotic; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eesperamicin-a1.html

Solubility

10 mM in DMSO

Smiles

CSSSC/C=C1C2=C(C([C@@H](O[C@@]3([H])C[C@@H]([C@H](O)[C@H](C)O3)OC(C4=C(C=C(OC)C(OC)=C4)NC(C(OC)=C)=O)=O)[C@]\1(C#C/C=C\C#C[C@@H]2O[C@@]5([H])[C@@H]([C@H]([C@H](NO[C@H]6C[C@@H]([C@H](SC)[C@@H](C)O6)O)[C@@H](C)O5)O)O[C@@]7([H])C[C@@H]([C@@H](NC(C)C)CO7)OC)O)=O)NC(OC)=O

Molecular Formula

C59H80N4O22S4

Molecular Weight

1325.54

References & Citations

[1]Lam, K. S., et al. Biosynthesis of esperamicin A1, an enediyne antitumor antibiotic. Journal of the American Chemical Society, 115 (26), 12340–12345.