Bryostatin 1
Product Specifications
UNSPSC Description
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties[1][2][3][4].
Target Antigen
Bacterial; HIV; PKC
Type
Natural Products
Related Pathways
Anti-infection;Epigenetics;TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bryostatin-1.html
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic;warming)
Smiles
O[C@]12[C@H](/C(C[C@](C[C@](OC(C[C@@H](C[C@@]3([H])O[C@](O)(C(C)([C@@H](OC(C)=O)C3)C)C[C@@](C/4)([H])O[C@@](CC4=C/C(OC)=O)([H])/C=C/C2(C)C)O)=O)([H])[C@H](O)C)([H])O1)=C/C(OC)=O)OC(/C=C/C=C/CCC)=O
Molecular Weight
905.03
References & Citations
[1]Blanco FA, et al. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 Jul 9;58(27):3016-3030.|[2]Kornberg MD, et al. Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2186-2191.|[3]Zeng N, et al. Bryostatin 1 causes attenuation of TPA-mediated tumor promotion in mouse skin. Mol Med Rep. 2018 Jan;17(1):1077-1082.|[4]Proust A, et al. HIV-1 infection and latency-reversing agents bryostatin-1 and JQ1 disrupt amyloid beta homeostasis in human astrocytes. Glia. 2020 Apr 6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105231/Bryostatin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105231/Bryostatin-1-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
83314-01-6
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