Bryostatin 1

Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS) -permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties[1][2][3][4].

Product Specifications

CAS Number

[83314-01-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H373

Target

Bacterial; HIV; PKC

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bryostatin-1.html

Purity

99.70

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

O[C@]12[C@H](/C(C[C@](C[C@](OC(C[C@@H](C[C@@]3([H])O[C@](O)(C(C)([C@@H](OC(C)=O)C3)C)C[C@@](C/4)([H])O[C@@](CC4=C/C(OC)=O)([H])/C=C/C2(C)C)O)=O)([H])[C@H](O)C)([H])O1)=C/C(OC)=O)OC(/C=C/C=C/CCC)=O

Molecular Formula

C47H68O17

Molecular Weight

905.03

Precautions

H315, H319, H335, H373

References & Citations

[1]Blanco FA, et al. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. 2019 Jul 9;58 (27) :3016-3030.|[2]Kornberg MD, et al. Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 2018 Feb 27;115 (9) :2186-2191.|[3]Zeng N, et al. Bryostatin 1 causes attenuation of TPA-mediated tumor promotion in mouse skin. Mol Med Rep. 2018 Jan;17 (1) :1077-1082.|[4]Proust A, et al. HIV-1 infection and latency-reversing agents bryostatin-1 and JQ1 disrupt amyloid beta homeostasis in human astrocytes. Glia. 2020 Apr 6.