Fabesetron
Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy[1][2].
Product Specifications
CAS Number
[129300-27-2]
Product Name Alternative
FK1052 (free base)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fabesetron.html
Purity
95.72
Solubility
10 mM in DMSO
Smiles
O=C1N2C3=C(C=CC=C3)C(C)=C2CC[C@@H]1CC4=C(NC=N4)C
Molecular Formula
C18H19N3O
Molecular Weight
293.36
References & Citations
[1]M Kadowaki, et al. Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 1993 Jul;266 (1) :74-80.|[2]Hiroe Nakayama, et al. Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets. J Pharmacol Sci. 2005 Aug;98 (4) :396-403.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Apolipoprotein D; lactoferrin
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6274033-01 0.1 mL
AP1M1, ID (AP1M1, CLTNM, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 mu-1 subunit, Adaptor-related protein complex 1 mu-1 subunit, Clathrin assembly protein complex 1 medium chain 1, Clathrin coat assembly prote
Ask
View Details 
MBS6274033-02 5x 0.1 mL
AP1M1, ID (AP1M1, CLTNM, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 mu-1 subunit, Adaptor-related protein complex 1 mu-1 subunit, Clathrin assembly protein complex 1 medium chain 1, Clathrin coat assembly prote
Ask
View Details 