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TAK 044

TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction, acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage[1].

Product Specifications

CAS Number

[157380-72-8]

UNSPSC

12352209

Target

Endothelin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tak-044.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@H](C1=CC=CS1)NC([C@@H](NC([C@@H](NC([C@H](NC2=O)CC(O[Na])=O)=O)CC(N3CCN(C4=CC=CC=C4)CC3)=O)=O)CC(O[Na])=O)=O)=O)CC(C)C)N[C@@H]2CC5=CNC6=CC=CC=C56

Molecular Formula

C45H51N9Na2O11S

Molecular Weight

971.98

References & Citations

[1]Toshifumi Watanabe, et al. TAK-044: An Endothelin Receptor Antagonist. , 14 (1), 36–46.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-105168/TAK-044-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-105168/

Scientific Category

Peptides

Clinical Information

Phase 2

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