Eritoran

Product Specifications

CAS Number

185955-34-4

UNSPSC Description

Eritoran （E5564 free base） is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection. Eritoran has anti-inflammatory activity[1][2].

Target Antigen

EBV; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Anti-infection;Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/eritoran.html

Solubility

10 mM in DMSO

Smiles

CCCCCCC[C@@H](OC)CCO[C@@H]1[C@H]([C@@H](O[C@H](COC)[C@H]1OP(O)(O)=O)OC[C@@H]2[C@H]([C@@H]([C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(O)(O)=O)O2)OCCCCCCCCCC)O)NC(CCCCCCCCC/C=C\CCCCCC)=O

Molecular Weight

1313.66

References & Citations

[1]Younan P, et al. The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge. mBio. 2017 Apr 25;8(2):e00226-17. |[2]Sun Y, et al. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1247-54.