Zoniporide (dihydrochloride)

Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1) . Zoniporide dihydrochloride inhibits NHE1 dependent 22Na+ uptake in vitro with an IC50 of 14 nM. Zoniporide has antitumor activity[1][2].

Product Specifications

CAS Number

[241799-10-0]

Product Name Alternative

CP-597396 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zoniporide-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O.[H]Cl.[H]Cl

Molecular Formula

C17H18Cl2N6O

Molecular Weight

393.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Marala RB, et al. Zoniporide: a potent and highly selective inhibitor of human Na (+) /H (+) exchanger-1. Eur J Pharmacol. 2002 Sep 6;451 (1) :37-41.|[2]Sanhueza C, et al. Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863 (1) :81-91.