Tiospirone
Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].
Product Specifications
CAS Number
87691-91-6
Product Name Alternative
BMY 13859-1 (free base)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tiospirone.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCCCN2CCN(CC2)C3=NSC4=C3C=CC=C4)C(CC5(CCCC5)C1)=O
Molecular Formula
C24H32N4O2S
Molecular Weight
440.60
References & Citations
[1]Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68 (1-2) :93-8.|[2]Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52 (8) :977-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor;5-HT7 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
