Tiospirone

Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].

Product Specifications

CAS Number

[87691-91-6]

Product Name Alternative

BMY 13859-1 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tiospirone.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CCCCN2CCN(CC2)C3=NSC4=C3C=CC=C4)C(CC5(CCCC5)C1)=O

Molecular Formula

C24H32N4O2S

Molecular Weight

440.60

References & Citations

[1]Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68 (1-2) :93-8.|[2]Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52 (8) :977-81.