Canagliflozin-d6
Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].
Product Specifications
Product Name Alternative
JNJ 28431754-d6
UNSPSC
12352005
Target
SGLT
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1C2=CC(C([2H])(C3=CC=C(S3)C4=C(C([2H])=C(C([2H])=C4[2H])F)[2H])[2H])=C(C=C2)C)CO)O)O
Molecular Formula
C24H19D6FO5S
Molecular Weight
450.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Liang Y, et al. 
 Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.
 PLoS One. 2012;7 (2) :e30555.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
SGLT2
Frequently Asked Questions
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