R916562
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis[1].
Product Specifications
CAS Number
1037798-41-6
UNSPSC
12352005
Target
TAM Receptor; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/R916562.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(NC(C=C2)=CC=C2N3CCN([C@H]4[C@@H]5CC[C@@H](C5)C4)CC3)=NN1C6=NC(Cl)=NC7=C6SC=C7C
Molecular Formula
C26H30ClN9S
Molecular Weight
536.09
References & Citations
[1]Goff D, et al. Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy. Bioorg Med Chem Lett. 2017 Aug 15; 27 (16) :3766-3771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; VEGFR2/KDR/Flk-1
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