AMG8788
AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM[1].
Product Specifications
CAS Number
1159996-43-6
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amg8788.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2=C(C=CC=C2)[C@H]1C3=CC=C(C(F)(F)F)C=C3)NC4=CC=C(F)C=C4
Molecular Formula
C23H18F4N2O
Molecular Weight
414.40
References & Citations
[1]Gavva NR, et al. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain. 2012 May 9;8:36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1; TRPM8
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