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L-Kynurenine-13C10 (sulfate hemihydrate)

L-Kynurenine-13C10 (sulfate hemihydrate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[1][2].

Product Specifications

UNSPSC

12352211

Target

Aryl Hydrocarbon Receptor; Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-kynurenine-13c10-sulfate-hemihydrate.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

O[13C]([13C@@](N)[13C][13C]([13C]1=[13C]([13C]=[13C][13C]=[13C]1)N)=O)=O.O=S(O)(O)=O.[1/2].O

Molecular Formula

13C10H7N2O7S.1/2H2O

Molecular Weight

318.17

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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