L-Kynurenine-13C10 (sulfate)
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[1][2].
Product Specifications
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-kynurenine-13c10-sulfate.html
Solubility
10 mM in DMSO
Smiles
O[13C]([13C@H]([13CH2][13C]([13C]1=[13C](N)[13CH]=[13CH][13CH]=[13CH]1)=O)N)=O.O=S(O)(O)=O
Molecular Formula
13C10H14N2O7S
Molecular Weight
316.22
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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