L-Kynurenine (sulfate)

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[1].

Product Specifications

CAS Number

[16055-80-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Aryl Hydrocarbon Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-kynurenine-sulfate.html

Solubility

10 mM in DMSO

Smiles

O=S(O)(O)=O.O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O

Molecular Formula

C10H14N2O7S

Molecular Weight

306.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.