MAK683 (hydrochloride)
Product Specifications
UNSPSC Description
MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay[1][2].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mak683-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=CC=C1C2=CN=C(NCC3=C4CCOC4=CC=C3F)N5C2=NN=C5.Cl
Molecular Weight
412.85
References & Citations
[1]Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.|[2]Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103663A/MAK683-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103663A/
Clinical Information
Phase 1
CAS Number
2170606-94-5
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