AP 24149

AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

Product Specifications

CAS Number

[926922-29-4]

UNSPSC

12352005

Target

Bcr-Abl; Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap-24149.html

Solubility

10 mM in DMSO

Smiles

O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2

Molecular Formula

C23H24N5OP

Molecular Weight

417.44

References & Citations

[1]Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75 (1) :18-28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Abl

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

BT-AP09650-01 20 µL

EP3A Rabbit Polyclonal Antibody

Ask

View Details

BT-AP09650-02 50 µL

EP3A Rabbit Polyclonal Antibody

Ask

View Details

BT-AP09650-03 100 µL

EP3A Rabbit Polyclonal Antibody

Ask

View Details

ICH2250-50mg 50 mg

Mouse IgG2b (MPC-11) Isotype Control for In Vivo - Low Endotoxin

Ask

View Details

QH76729S 200 Tests

Human C14orf180 qPCR Primer Pair

Ask

View Details

AMM18274V 100 µL

FGFBP1 Mouse Monoclonal Antibody [Clone ID: LBI7D10]

Ask

View Details