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(S, R, S) -AHPC-PEG3-NH2 (dihydrochloride)

(S, R, S) -AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1]

Product Specifications

CAS Number

2376990-24-6

Product Name Alternative

VH032-PEG3-NH2 (dihydrochloride) ; VHL Ligand-Linker Conjugates 1 (dihydrochloride) ; E3 ligase Ligand-Linker Conjugates 5 (dihydrochloride)

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-peg3-nh2-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C3.[H]Cl

Molecular Formula

C30H47Cl2N5O7S

Molecular Weight

692.69

References & Citations

[1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61 (2) :504-513.|[2]Salami J, et al. Waste disposal-An attractive strategy for cancer therapy. Science. 2017;355 (6330) :1163-1167.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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