MFZ 10-7 (hydrochloride)
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
1779796-36-9
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mfz-10-7-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1.[H]Cl
Molecular Formula
C15H10ClFN2
Molecular Weight
272.70
References & Citations
[1]Thomas M Keck, et al. A Novel mGluR5 Antagonist, MFZ 10-7, Inhibits Cocaine-Taking and Cocaine-Seeking Behavior in Rats. Addict Biol . 2014 Mar;19 (2) :195-209.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
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