VU0285683

VU0285683 is a selective mGluR5 positive allosteric modulator (PAM) . VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].

Product Specifications

CAS Number

[327056-22-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0285683.html

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C2=NC(C3=NC=CC=C3)=NO2)=CC(F)=C1

Molecular Formula

C14H7FN4O

Molecular Weight

266.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78 (6) :1105-23.