Desmethyl-YM-298198 (hydrochloride)

Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM) . Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753) -induced hyperalgesic mice[1].

Product Specifications

CAS Number

[1177767-57-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desmethyl-ym-298198-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)NC4CCCCC4.[H]Cl

Molecular Formula

C17H21ClN4OS

Molecular Weight

364.89

Precautions

P261-P280-P302+P352

References & Citations

[1]Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315 (1) :163-9.