ACDPP

ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist) [1].

Product Specifications

CAS Number

[37804-11-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acdpp.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(Cl)=C(N(C)C)N=C1N)NC2=NC=CC=C2

Molecular Formula

C12H13ClN6O

Molecular Weight

292.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang H, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28 (17) :4385-97.