ACDPP
ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (group I mGluR Agonist).
Product Specifications
CAS Number
37804-11-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/acdpp.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(Cl)=C(N(C)C)N=C1N)NC2=NC=CC=C2
Molecular Formula
C12H13ClN6O
Molecular Weight
292.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang H, et al. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28 (17) :4385-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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