(±) -LY395756

(±) -LY395756 is an agonist of mGlu2 receptor and an antagonist of mGlu3 receptor. (±) -LY395756 can distinguish the native mGlu2 and mGlu3 receptors[1].

Product Specifications

CAS Number

[852679-66-4]

UNSPSC

12352211

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-ly395756.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])[C@H](C)C1)O

Molecular Formula

C9H13NO4

Molecular Weight

199.20

References & Citations

[1]Ceolin L, et al. Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype. J Neurosci. 2011 May 4;31 (18) :6721-31.