A-841720

A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].

Product Specifications

CAS Number

[869802-58-4]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-841720.html

Purity

98.0

Solubility

DMSO : 15 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=C(C3=C(N(C)C)C=CN=C3S2)N=CN1N4CCCCCC4

Molecular Formula

C17H21N5OS

Molecular Weight

343.45

References & Citations

[1]O El-Kouhen, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006 Nov;149 (6) :761-74.|[2]Lorenzo Morè, et al. Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18 (4) :273-81.