[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P

[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P activates G12. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]

Product Specifications

CAS Number

[96736-12-8]

UNSPSC

12352209

Target

Bombesin Receptor; Interleukin Related; JNK

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/d-arg1-d-phe5-d-trp7-9-leu11-substance-p.html

Purity

98.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](CCC(N)=O)NC([C@@H](CC4=CC=CC=C4)NC([C@H]5N(CCC5)C([C@H](CCCCN)NC([C@H]6N(CCC6)C([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)=O

Molecular Formula

C79H109N19O12

Molecular Weight

1516.83

References & Citations

[1]Jarpe MB, et al. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J Biol Chem. 1998 Jan 30;273 (5) :3097-104.|[2]Woll PJ, Rozengurt E. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci U S A. 1988 Mar;85 (6) :1859-63.