3,5-Bis (4-nitrophenoxy) benzoic acid

3,5-Bis (4-nitrophenoxy) benzoic acid is an inhibitor of γ-secretase. 3,5-Bis (4-nitrophenoxy) benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25) . 3,5-Bis (4-nitrophenoxy) benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1].

Product Specifications

CAS Number

[173550-33-9]

UNSPSC

12352005

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-5-bis-4-nitrophenoxy-benzoic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=CC(OC3=CC=C([N+]([O-])=O)C=C3)=C1

Molecular Formula

C19H12N2O8

Molecular Weight

396.31

References & Citations

[1]Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61 (3) :307-312.|[2]Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10 (6) :e0128619. Published 2015 Jun 5.|[3]Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29.