CGP36216

CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders[1][2].

Product Specifications

CAS Number

[123691-29-2]

UNSPSC

12352211

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgp36216.html

Solubility

10 mM in DMSO

Smiles

O=P(CC)(CCCN)O

Molecular Formula

C5H14NO2P

Molecular Weight

151.14

References & Citations

[1]William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518.|[2]J Ong, et al. CGP 36216 is a selective antagonist at GABA (B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415 (2-3) :191-5.|[3]Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275.