TB-21007
TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats[1].
Product Specifications
CAS Number
207306-50-1
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tb-21007.html
Purity
99.7
Solubility
DMSO : 40 mg/mL (ultrasonic; warming)
Smiles
O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21
Molecular Formula
C15H17NO2S3
Molecular Weight
339.50
References & Citations
[1]Chambers MS, et al. Identification of a novel, selective GABA (A) alpha5 receptor inverse agonist which enhances cognition. J Med Chem. 2003 May 22;46 (11) :2227-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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