CGP7930
CGP7930 (3- (3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons[1].
Product Specifications
CAS Number
57717-80-3
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cgp7930.html
Purity
99.0
Solubility
DMSO : 29.25 mg/mL (ultrasonic; warming)
Smiles
OCC(C)(C)CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
Molecular Formula
C19H32O2
Molecular Weight
292.46
References & Citations
[1]Urwyler S, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid (B) receptors by 2,6-Di-tert-butyl-4- (3-hydroxy-2,2-dimethyl-propyl) -phenol (CGP7930) and its aldehyde analog CGP13501. Mol Pharmacol. 2001; 60 (5) :963-71.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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