CGP7930

CGP7930 (3- (3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator. CGP7930 enhances the inhibitory effect of l-baclofen on the oscillatory activity of cultured cortical neurons[1].

Product Specifications

CAS Number

[57717-80-3]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgp7930.html

Purity

99.0

Solubility

DMSO : 29.25 mg/mL (ultrasonic; warming)

Smiles

OCC(C)(C)CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Molecular Formula

C19H32O2

Molecular Weight

292.46

References & Citations

[1]Urwyler S, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid (B) receptors by 2,6-Di-tert-butyl-4- (3-hydroxy-2,2-dimethyl-propyl) -phenol (CGP7930) and its aldehyde analog CGP13501. Mol Pharmacol. 2001; 60 (5) :963-71.