SA57

SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases[1][2].

Product Specifications

CAS Number

[1346169-63-8]

UNSPSC

12352005

Target

FAAH; MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sa57.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC(CCC2=CC=C(Cl)C=C2)CC1)OCC(NC)=O

Molecular Formula

C17H23ClN2O3

Molecular Weight

338.83

References & Citations

[1]Niphakis MJ, et al. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2012 May 16;3 (5) :418-26.|[2]Owens RA, et al. Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice. J Pharmacol Exp Ther. 2016 Aug;358 (2) :306-14.