FERb 033
FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM) . FERb 033 shows 62-fold selectivity over ERα[1].
Product Specifications
CAS Number
1111084-78-6
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ferb-033.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C2=CC(F)=C(O)C=C2)C=CC(/C=N/O)=C1O
Molecular Formula
C13H9ClFNO3
Molecular Weight
281.67
References & Citations
[1]Filippo Minutolo, et al. Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem. 2009 Feb 12;52 (3) :858-67.|[2]Satomi Kohno, et al. Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. Endocrinology. 2015 May;156 (5) :1887-99.|[3]Sangeeta Bhallamudi, et al. Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318 (1) :L112-L124.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
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