A-77636 (hydrochloride)

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].

Product Specifications

CAS Number

[145307-34-2]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-77636-hydrochloride.html

Purity

98.0

Solubility

DMSO : 33 mg/mL (ultrasonic)

Smiles

[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3

Molecular Formula

C20H28ClNO3

Molecular Weight

365.89

References & Citations

[1]Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229 (2-3) :203-209.|[2]Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna) . 2002;109 (2) :123-140.|[3]Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532 (3) :253-257.