Nemonapride

Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals[1][2][3].

Product Specifications

CAS Number

[75272-39-8]

Product Name Alternative

YM-09151-2; Emonapride

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nemonapride.html

Purity

99.90

Solubility

DMF : 20 mg/mL (ultrasonic; warming)

Smiles

O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC

Molecular Formula

C21H26ClN3O2

Molecular Weight

387.90

Precautions

H302

References & Citations

[1]Terai M, et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol. 1983 Aug;33 (4) :749-55. |[2]Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15 (7) :264-70.|[3]Assié MB, et al. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur J Pharmacol. 1997 Sep 10;334 (2-3) :141-7.