SKF83822 (hydrobromide)

SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC) -coupled D1 receptors, but not phospholipase C (PLC) -coupled D1-like receptors[1].

Product Specifications

CAS Number

[74115-10-9]

UNSPSC

12352005

Hazard Statement

H301-H400

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/skf83822-hydrobromide.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(CC=C)CCC2=C1Cl.[H]Br

Molecular Formula

C20H23BrClNO2

Molecular Weight

424.76

Precautions

P264-P270-P273-P330-P391-P405-P501

References & Citations

[1]Mahomi Kuroiwa, et al. Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum. J Neurochem. 2008 Nov;107 (4) :1014-26.|[2]Aliya L Frederick, et al. Neurobehavioral phenotyping of G (αq) knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair. Front Behav Neurosci. 2012 Jun 19;6:29.