NBI-27914 (hydrochloride)
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4].
Product Specifications
CAS Number
1215766-76-9
UNSPSC
12352005
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nbi-27914-hydrochloride.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCN(C1=NC(C)=NC(NC2=C(C=C(Cl)C=C2Cl)Cl)=C1Cl)CC3CC3.Cl
Molecular Formula
C18H21Cl5N4
Molecular Weight
470.65
References & Citations
[1]Peng YL, et al. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31 (12) :2259-2263.|[2]Hummel M, et al. Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. Neuropharmacology. 2010;59 (3) :160-166.|[3]Baram TZ, et al. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997;770 (1-2) :89-95.|[4]Chen C, et al. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRFR1
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