NBI-27914 (hydrochloride)

NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4].

Product Specifications

CAS Number

[1215766-76-9]

UNSPSC

12352005

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nbi-27914-hydrochloride.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCN(C1=NC(C)=NC(NC2=C(C=C(Cl)C=C2Cl)Cl)=C1Cl)CC3CC3.Cl

Molecular Formula

C18H21Cl5N4

Molecular Weight

470.65

References & Citations

[1]Peng YL, et al. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31 (12) :2259-2263.|[2]Hummel M, et al. Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. Neuropharmacology. 2010;59 (3) :160-166.|[3]Baram TZ, et al. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997;770 (1-2) :89-95.|[4]Chen C, et al. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem.